Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties.

نویسندگان

  • Nuria Rodríguez-Vázquez
  • Rebeca García-Fandiño
  • Manuel Amorín
  • Juan R Granja
چکیده

The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups that modify the internal properties of the resulting dimeric ensemble. These dimers can entrap different guests depending on the properties of the group at C2. The guest defines the geometry of the resulting aggregate.

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عنوان ژورنال:
  • Chemical science

دوره 7 1  شماره 

صفحات  -

تاریخ انتشار 2016